Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?9/27/2023 1 Administration of recombinant t-PA in the setting of an acute thromboembolic event will result in clot dissolution, reperfusion of organs, and restoration of blood flow to tissues. Activity results in the breakdown of fibrin, fibrinogen, and other procoagulant proteins. Tissue plasminogen activator (t-PA) is a natural peptide that initiates fibrinolysis by binding to fibrin in a thrombus and converting the trapped plasminogen to plasmin.
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